Cutaneous Mastocytosis in an 8-year-old Child: Case Report and Review of the Literature
Tsveta Kalinova,
Valentina Broshtilova,
Yoanna Velevska-Vatova,
Sonya Marina
Issue:
Volume 5, Issue 1, June 2022
Pages:
1-5
Received:
10 August 2022
Accepted:
30 August 2022
Published:
14 September 2022
DOI:
10.11648/j.ijcd.20220501.11
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Abstract: Background: Mastocytosis is a clinical condition occurring from birth to adulthood. It mainly involves the skin solely or in association with other organs such as the liver, bone marrow, spleen and lymph nodes. A bimodal distribution presenting in children from birth to 2 years of age and in patients older than 15 is commonly described. Case Information: An eight-year-old male patient presented with macules and papules on the trunk and limbs for 6 months. The rash worsened after bathing and physical activity. Results: The symptoms were compatible with cutaneous mastocytosis and confirmed histologically. Conclusion: Patients with mastocytosis may be asymptomatic or have symptoms due to mast cells degranulation – itch, flush, headache, syncope, gastrointestinal complaints of abdominal pain and diarrhea. Diagnosis of cutaneous mastocytosis is based on clinical morphology of skin lesions, positive Darier`s sign and histological skin lesions stained for tryptase and/or CD117. Therapeutic management involves avoiding triggers, H1-/H2- receptor blockers and symptomatic medications. All patients with cutaneous mastocytosis require regular follow-up examinations.
Abstract: Background: Mastocytosis is a clinical condition occurring from birth to adulthood. It mainly involves the skin solely or in association with other organs such as the liver, bone marrow, spleen and lymph nodes. A bimodal distribution presenting in children from birth to 2 years of age and in patients older than 15 is commonly described. Case Inform...
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Cutaneous Manifestations in Chronic Hemodialysis Patients in Antananarivo Madagascar
Mendrika Fifaliana Rakotoarisaona,
Fandresena Arilala Sendrasoa,
Malalaniaina Andrianarison,
Onivola Raharolahy,
Naina Harinjara Razanakoto,
Moril Sata,
Volatantely Ratovonjanahary,
Irina Mamisoa Ranaivo,
Lala Soavina Ramarozatovo,
Fahafahantsoa Rapelanoro Rabenja
Issue:
Volume 5, Issue 1, June 2022
Pages:
6-10
Received:
9 August 2022
Accepted:
7 September 2022
Published:
16 September 2022
DOI:
10.11648/j.ijcd.20220501.12
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Abstract: Introduction: Skin manifestations in chronic hemodialysis patients are frequent and polymorphous. The pathogenesis of these skin manifestations is poorly elucidated. The aim of this study was to determine the prevalence and clinical characteristics of these skin lesions and to review the literature on their pathogenesis. Methods: A descriptive multicenter cross-sectional study over 2-month period (November to December 2017) was conducted among chronic hemodialysis patients in 5 dialysis centers in Antananarivo Madagascar. Results: The study included 129 patients, 79 men and 50 women with a mean age of 53.4 years. The average duration of hemodialysis was 32.1 months. All patients presented at least one skin manifestation. Skin xerosis (72.97%), hyperpigmentation (70.54%) and pruritus (58.14%) were the most frequent specific signs of hemodialysis. Other non-specific signs found were acne (10.5%), prurigo (0.7%), ecchymosis (1.55%) and skin infections (10.8%). Only two patients had Kyrle's disease. Exoskeleton abnormalities were found in 44.19% of cases, represented essentially by onychomycosis (50%). According to our study, these cutaneous manifestations were not related to age or gender. Conclusion: Skin manifestations in chronic hemodialysis patients are frequent and deserve to be known by dermatologists. A good management of these conditions can reduce their prevalence and thus improve patient’s quality of life.
Abstract: Introduction: Skin manifestations in chronic hemodialysis patients are frequent and polymorphous. The pathogenesis of these skin manifestations is poorly elucidated. The aim of this study was to determine the prevalence and clinical characteristics of these skin lesions and to review the literature on their pathogenesis. Methods: A descriptive mult...
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