Serum Vitamin B12 and Folic Acid in Vitiligo Patients: A Case Control Study
Nadia Abdalhafid El Sherif,
Salwa Abdalsalam El-Dibany,
Azza El Saddiek Hussein Greiw
Issue:
Volume 3, Issue 2, December 2020
Pages:
19-21
Received:
14 August 2020
Accepted:
24 August 2020
Published:
16 September 2020
DOI:
10.11648/j.ijcd.20200302.11
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Abstract: Background: Vitiligo is an autoimmune disease characterized by the destruction of melanocytes by immune mechanisms. The role of vitamin B12 and folate in melanin synthesis has been well recognized. Aim of the study: To evaluate the serum levels of vitamin B12 and folate in Libyan patients with vitiligo vulgaris. Patients and Methods: Blood samples for haemoglobin (Hb) level, mean corpuscular volume (MCV), serum levels of Vitamin B12 and folate were obtained from 50 patients with vitiligo vulgaris and 50 age and sex-matched healthy controls at Dermatology Department of Eljumhoria Hospital in Benghazi, Libya. Results: 50 patients with vitiligo vulgaris, with mean of age 34±6 years, 34% had active disease. Blood Hb level was non-significantly lower in 26% vitiligo patients as compared to 16% control subjects (P=0.064). A significant difference was observed regarding the MCV level which was lower in vitiligo patients in comparison to that of control subjects (P=0.03). 38% of vitiligo patients have microcytic anemia (P=0.142). None of the patients has macrocytic anemia. Female patients were found to have significantly lower Hb and lower MCV than males (P=.000). Serum vitamin B12 and folate were lower in patients than control subjects and this difference was statistically significant (P=.05, P=0.001). There was no significant correlation between serum levels of vitamin B12 and folate with sex, age, family history, duration and activity of the disease ( P >0.05). Conclusions: Decreased levels of serum vitamin B12 and folate are significantly prevalent in vitiligo patients, and screening vitiligo patients for vitamin B12 and folate deficiency may be warranted.
Abstract: Background: Vitiligo is an autoimmune disease characterized by the destruction of melanocytes by immune mechanisms. The role of vitamin B12 and folate in melanin synthesis has been well recognized. Aim of the study: To evaluate the serum levels of vitamin B12 and folate in Libyan patients with vitiligo vulgaris. Patients and Methods: Blood samples ...
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A Study of Dermatological Diseases in a Geriatric Patients
Najat Omer Ali Alramaity,
Nadia Abdalhafid Elsherif,
Azza El Saddiek Hussein Greiw
Issue:
Volume 3, Issue 2, December 2020
Pages:
22-27
Received:
4 October 2020
Accepted:
19 October 2020
Published:
11 November 2020
DOI:
10.11648/j.ijcd.20200302.12
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Abstract: Background: The dermatological problems in the elderly is very common, and can often add to the psychological stress in the geriatric population. Aim of the study: To determine the frequency and the patterns of skin diseases in the elderly patients. Patients and methods: A cross-sectional study was done in 100 elderly patients who attended the dermatology outpatients department in Benghazi city, from April 2018 to December 2018, females aged 50 years and above and males aged 60 years and above were evaluated for dermatological diseases. Results: Hundred elderly patients were enrolled in the study 68% were females and 32% were males. The inflammatory dermatoses were the commonest findings seen in 60% of patients, cutaneous infections seen in 36% of patients and cutaneous vascular disorders seen in 4% of patients. Eczema was the commonest inflammatory dermatosis seen in 22% of patients, pruritus was seen in 20% of patients. Seborrheic dermatitis was the commonest type of eczema seen in 9% of patients. The various types of cutaneous infections, fungal infections were seen in 15% of patients, bacterial infections seen in 14% of patients and viral infections seen in 7% of patients. Tinea pedis was the commonest seen in 10% of patients. Fungal infections were more common in female patients. Conclusions: Structural and physiological changes in aged skin can produce marked susceptibility to dermatological disorders. The inflammatory dermatosis was the most prevalent skin diseases in the elderly patients, and eczema were the predominant inflammatory dermatosis.
Abstract: Background: The dermatological problems in the elderly is very common, and can often add to the psychological stress in the geriatric population. Aim of the study: To determine the frequency and the patterns of skin diseases in the elderly patients. Patients and methods: A cross-sectional study was done in 100 elderly patients who attended the derm...
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Comparative Clinical Assessment of Effectiveness and Safety of Calcitriol and Calcipotriol in Mild Plaque Psoriasis
Harshal Mahajan,
Gaurav Deshmukh,
Dhiraj Dhoot,
Rashmi Mamadi,
Hanmant Barkate
Issue:
Volume 3, Issue 2, December 2020
Pages:
28-31
Received:
29 October 2020
Accepted:
9 November 2020
Published:
19 November 2020
DOI:
10.11648/j.ijcd.20200302.13
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Abstract: Introduction: Psoriasis is defined as chronic disease of the skin which is treated by topical drugs, systemic drugs or phototherapy depending on its severity. Vitamin D analogues are also commonly used in psoriasis, and its combination with topical corticosteroids (TCS) has shown to have synergistic action leading to more effective control of symptoms of psoriasis as well as decrement in adverse events like skin atrophy associated with prolonged TCS therapy. The present study was undertaken in pursuit of comparative assessment of effectiveness and safety of calcitriol and calcipotriol in patients diagnosed with mild psoriasis. Material and methods: This was a multicentre, retrospective data analysis and comparison between calcitriol and calcipotriol ointment done at 129 dermatology clinics across India after obtaining ethics committee approval. The data charts were identified by generating a list of all patients who were prescribed clobetasol and calcitriol as fixed dose combination for 2 weeks followed by either calcitriol (group 1) or calcipotriol (group 2) for 4 weeks at all clinics, using medical record database. Results: Out of 1076 records, a total of 630 patients met inclusion criteria. Improvement in symptoms was seen in all patients. Improvement in Physician Global assessment Score (PGAS) and Psoriasis Area and Severity Score (PASI) was seen consistently throughout the treatment period in both the groups, but greater improvement was seen in calcitriol group as compared to calcipotriol group at day 42 (p<0.05). Overall, the adverse effects in calcitriol group were less as compared to calcipotriol group. Conclusion: The findings of the present study suggests that calcitriol offers better effectiveness and safety over calcipotriol in maintenance phase of treatment of mild to moderate psoriasis and also it can serve as better option to maximise the therapeutic effect of topical corticosteroid as a fixed dose combination in acute phase of treatment.
Abstract: Introduction: Psoriasis is defined as chronic disease of the skin which is treated by topical drugs, systemic drugs or phototherapy depending on its severity. Vitamin D analogues are also commonly used in psoriasis, and its combination with topical corticosteroids (TCS) has shown to have synergistic action leading to more effective control of sympt...
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